Jak oddać próbkę do projektu G4PL w Poznaniu?
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Please fill out the questionnaire
Fill in the online form. If you are unable to do so, you can complete a paper version later.
Come to the Institute
Please contact the Institute of Bioorganic Chemistry of the Polish Academy of Sciences in Poznań to register for the project and sign the documents.
Wtorki i Czwartki: 7:30-9:00 i 16:00-17:30
Institute of Bioorganic Chemistry (Main Entrance)
19 Henryka Wieniawskiego Street
61-713 Poznan
Środy: 8:30-9:30 i 15:00-16:00.
Institute of Bioorganic Chemistry CIES Villa (Entrance K3, via the gate on Wieniawskiego
Street)
Wieniawskiego 21/23
61-713 Poznan
Collect your identification number
Once you have signed the consent form, you will be given your participant number.
Donate a blood sample
Please go to OPEN Biobank with your identification number.
Blood samples collection: Mon.–Fri., 8.00 am–2.30 pm Office 16 (ground floor).
Who can take part in the project?
We welcome participants who are not related. This means that, for example, a husband and wife may take part in the project, whereas we do not normally collect samples from close relatives, such as a parent and child or siblings.
Participation involves providing a sample and giving informed consent to take part in the project. It is possible to provide samples at a later date.
What are the benefits?
By taking part in the project:
You can receive a free report on your genome, containing information on, amongst other things, your genetic ancestry.
You are supporting the development of Polish science and medicine.
You are helping to build a more accurate picture of the genetic diversity of Poland’s population.
You are doing your bit to advance healthcare diagnostics and prevention.
Why is this important?
Genomic research makes it possible to seek answers to specific questions, such as:
What is the genetic origin of the people of Poland?
Could a person have an increased predisposition to certain diseases?
Could a person react differently to certain medicines?
How can we better tailor prevention and treatment to the individual?
Frequently Asked Questions
1. Is it possible to send a sample directly? Or can samples only be collected in person?
At this stage of the project, we do not foresee the possibility of sending samples by post or courier. Currently, samples are collected exclusively at designated collection points, in accordance with a standardised procedure, to ensure their quality and the comparability of results.
However, at a later stage of the project, we plan to introduce the option of accepting samples sent by post. This solution is intended to help ensure a more even collection of samples from participants across Poland. You will be able to collect a saliva sample yourself, once you have received a kit from us along with instructions. Information on this will also be posted on the project website.
2. How much does it cost?
The analysis included in the project is free of charge for all qualified participants.
3. What will be studied, and how?
The analysis involves whole-genome sequencing, i.e. the sequencing of the complete genetic information (DNA) of the person providing the sample. Modern high-throughput DNA sequencing technology will be used for this purpose.
4. Are there any criteria that would exclude someone from taking part in the study or
providing a sample (e.g. blood transfusions or bone marrow transplants)?
In most cases, it is possible to take part in the project. Simply being a blood donor or a bone marrow donor does not preclude participation in the study.
However, there are situations that may affect the quality of the sample and the interpretation of the result:
- as a general rule, people who have undergone a bone marrow or haematopoietic cell transplant should not provide a blood sample, as the blood cells may originate from the donor rather than the participant. A bone marrow transplant can lead to so-called chimerism in blood cells, which may hinder or prevent the correct interpretation of the results of a DNA test from blood.
- Following a blood transfusion, you must wait at least 2 weeks before providing a sample. In the case of a transfusion, the effect on the result is usually temporary; this is why a deferral period is applied. In our project, we apply a rule of at least 2 weeks.
In the event of other specific medical circumstances, the decision may require individual consultation with the project team.
5. Will every sample be sequenced?
Given the project’s objectives, which involve collecting a sample set that is evenly representative of the whole country and reflects the population’s gender and age structure, it is possible that applications may be selected on the basis of the information provided in the questionnaire. DNA samples will also undergo quality control, the results of which may mean that a sample is ultimately not selected for sequencing.
6. Will this research be conducted only in Poznań?
Sampling will take place not only in Poznań, but also at other centres belonging to the G4PL consortium. The exact dates and locations have not yet been finalised for all sites. As soon as further sampling dates are confirmed, the information will be published on the G4PL project website. We encourage you to check the ‘News’ section on the project website regularly.
7. As a participant in the study, what specific medical information can you receive about your
DNA profile? Information about specific mutations that may predispose you to certain
diseases?
Participants will receive information regarding so-called uniparental markers, namely an analysis of haplotypes and assignment to mitochondrial DNA haplogroups and, in the case of men, to Y-chromosome haplogroups. This analysis provides information on the approximate genetic ancestry on the maternal and paternal lines.
In addition, participants will be provided with information on selected pathogenic or likely pathogenic variants, in accordance with the recommendations of the American College of Medical Genetics and Genomics (ACMG). The ACMG list includes genes associated, amongst other things, with a predisposition to cancer, cardiovascular diseases and selected metabolic disorders, for which there are reasonable possibilities for prevention, monitoring or treatment. The list of genes can be found on the website https://search.clinicalgenome.org/kb/genes/acmgsf?page=1&size=25&order=asc&sort=symbol&search=
Important: the report provided to the participant will not constitute a medical diagnosis. Any potentially significant result should be discussed with and confirmed by a doctor, a laboratory diagnostician specialising in medical genetics, or a genetic counselling service.
8. Do you need to be on an empty stomach?
No, you do not need to fast before having a blood sample taken.
For those who are unable to have a blood sample taken, a saliva sample may be collected instead. In this case, please brush your teeth before the sample is taken, and then refrain from eating, drinking, chewing gum or smoking for at least an hour. This helps to ensure a better-quality sample.
9. Is it necessary to register in advance or confirm attendance at the sampling session to
ensure that samples are taken from all those who have registered?
No, you do not need to book in advance to have a sample taken.
However, the number of samples that can be taken on a given date may be limited. In such cases, the order in which participants arrive may determine who has a sample taken.
10. Do I need to bring any documents with me (e.g. proof of identity, my child’s documents or
any other required forms)?
No form of identification is required to provide a sample, and the team conducting the collection does not verify personal details. However, please bear in mind that by signing the project documents, you are certifying that the information provided is entirely accurate.
11. Can I bring my family?
Yes, you can come with your family, but it is worth remembering that the project generally collects samples from people who are not biologically related; therefore, as a rule, we do not collect samples from close relatives, such as a parent and child or siblings. For this reason, a husband and wife may take part in the study.
Samples from children will be collected in specific cases relating to rare diseases.
12. Where will the research take place?
The sequencing results will be analysed in the laboratories of the project partners, located in Poland. The data generated by the sequencing will be stored in a secure repository, also located within the country. With the donors’ consent, some of the data will be transferred in anonymised form for the purposes of the Genome of Europe (GoE) , as Poland’s representative on the reference genetic map of Europe. The GoE is led by the Medical University of Rotterdam (Erasmus Medical Centre), and its partners are the two institutions carrying out the G4PL project – the Institute of Bioorganic Chemistry of the Polish Academy of Sciences and the University of Łódź.
13. Do I need to register before giving a blood sample?
No. You don’t need to register to give a blood sample.
You can give a blood sample at OPEN — Centre for Cancer Prevention and Epidemiology at
24/26 Kazimierza Wielkiego Street in Poznań:
https://maps.app.goo.gl/uAphGALipfai6B2z9
Sample collections take place from Monday to Friday between 8.00 am and 2.30 pm..
To provide a blood sample, you must have the participant ID issued during your visit to the Institute of Bioorganic Chemistry of the Polish Academy of Sciences. You do not need to fast before the blood sample is taken.
You can provide the blood sample immediately after your visit to the Institute of Bioorganic Chemistry of the Polish Academy of Sciences or later. However, please do not delay in providing the sample.
14. Can I avoid coming to the Institute of Bioorganic Chemistry of the Polish Academy of
Sciences to fill out the forms and simply hand in a blood sample straight away?
No, that is not possible.
Before giving a blood sample, you must sign the informed consent form in person to take part in the project. During your visit, you will also have the opportunity to ask the project coordinators any questions you may have. Only after signing the documents will you be given an identification number, which is essential for the correct labelling of your blood sample.